Members of the bacterial species in the person's intestine may protect against or increase the susceptibility of Campylobacter, the most common cause of human bacterial intestinal infection, according to a study published this week, mBio ®, American Society for Microbiology open access online journal. The study also found that Campylobacter infection can produce permanent changes in the composition of one of the intestinal bacteria."It is well known for a long time that the microbiota or micro-organisms in the intestines, can protect the person in the colonization of microorganisms that cause gastrointestinal illness. However, very little is known about how the human gut microbiota affects the susceptibility of these organisms, and for Campylobacter, "said senior study author Mahesh, m.d., a professor in clinical bacteriology Rautelin at Uppsala University and Uppsala University Hospital in Sweden. "We wanted to see if the human intestinal microbiota composition has a role in the susceptibility of Campylobacter infection."
Rautelin and colleagues after 24 workers at three slaughterhouses and poultry in Sweden. In 2010, they collected fecal samples from workers once a month during the summer, from June to September of Campylobacter-positive top chicken flocks, and again the following February. Fecal samples were cultured for Campylobacter and analyzed by sequencing all of the bacteria. Even if all the participants tested negative for Campylobacter at the beginning of the investigation, the seven participants came to a positive culture of the organism during the investigation. Campylobacter-positive just as experienced symptoms of the disease.
Those who cameCampylobacter-positive had significantly higher abundanceBacteroidesjaEscherichia Coliorganisms than those who continue to culture negative, which refers to the fact that these bacterial species has an important role in the colonization of the resistance.This group also had significantly greater abundance of Phascolarctobacterium and Streptococcus as Campylobacter-negative group, which was Lachnospiraceae and Anaerovorax, unclassified Clostridiales overrepresentation species.
A "high proportion of Bacteroides species and Escherichia coli intestinal microbiota can expose people, Campylobacter infection," Rautelin said. "Those species have been found to play an important role in the susceptibility of gut pathogens and Campylobacter, in particular in some mouse model studies."
The following persons to the fecal microbiota in the compositions of the time, the researchers found, Campylobacter-negative individuals had small differences, but those who tested positive for Campylobacter showed significant changes in February of the sample. Scientists do not yet know the effects of these changes, Rautelin said.
Whether the composition of the microbiota, alone or in an individual's immune system also play an important role in the eradication of Campylobacter casings must be investigated, he said.
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